Copaiba is tapped from Amazonian trees as an oleoresin, then distilled. Between two fifths and half of it is beta-caryophyllene, more than almost any other oil. That compound acts on the CB2 cannabinoid receptor, the one outside the brain, so it has no psychoactive effect at all. In arthritic rats it reduced inflammation and oxidative stress.^[1] In a double-blind placebo-controlled trial, topical copaiba reduced acne lesion counts, one of the few human trials of any essential oil for skin.^[2]